Ontology highlight
ABSTRACT:
SUBMITTER: Hoare T
PROVIDER: S-EPMC3065496 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Hoare Todd T Timko Brian P BP Santamaria Jesus J Goya Gerardo F GF Irusta Silvia S Lau Samantha S Stefanescu Cristina F CF Lin Debora D Langer Robert R Kohane Daniel S DS
Nano letters 20110223 3
Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. We show that the dose of drug delivered across the membrane can be tuned by engineering the phase transition temperature of the nanogel, the loading density of nanogels in the membrane, and the membrane thickness, allowing for on-state deliv ...[more]