Ontology highlight
ABSTRACT:
SUBMITTER: Dupre A
PROVIDER: S-EPMC3065498 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Dupré Aude A Boyer-Chatenet Louise L Sattler Rose M RM Modi Ami P AP Lee Ji-Hoon JH Nicolette Matthew L ML Kopelovich Levy L Jasin Maria M Baer Richard R Paull Tanya T TT Gautier Jean J
Nature chemical biology 20080106 2
The MRN (Mre11-Rad50-Nbs1)-ATM (ataxia-telangiectasia mutated) pathway is essential for sensing and signaling from DNA double-strand breaks. The MRN complex acts as a DNA damage sensor, maintains genome stability during DNA replication, promotes homology-dependent DNA repair and activates ATM. MRN is essential for cell viability, which has limited functional studies of the complex. Small-molecule inhibitors of MRN could circumvent this experimental limitation and could also be used as cellular r ...[more]