Ontology highlight
ABSTRACT:
SUBMITTER: Gille H
PROVIDER: S-EPMC306589 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Gille H H Kowalski J J Yu L L Chen H H Pisabarro M T MT Davis-Smyth T T Ferrara N N
The EMBO journal 20000801 15
Vascular endothelial growth factor (VEGF) has two highly homologous tyrosine kinase receptors: Flt-1 (VEGFR-1) and KDR (VEGFR-2). KDR is strongly phosphorylated on tyrosines and can transmit mitogenic and motogenic signals following VEGF binding, while Flt-1 is markedly less effective in mediating such functions. To dissect the regions that account for the differences between the two receptors, we generated a series of chimeric Flt-1-KDR molecules. We found that the juxtamembrane region of Flt-1 ...[more]