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Genetic effects on postprandial variations of inflammatory markers in healthy individuals.

ABSTRACT: Circulating levels of inflammatory markers predict the risk of cardiovascular disease (CVD), mediated perhaps in part by dietary fat intake, through mechanisms only partially understood. To evaluate post-fat load changes in inflammatory markers and genetic influences on these changes, we administered a standardized high-fat meal to 838 related Amish subjects as part of the Heredity and Phenotype Intervention (HAPI) Heart Study and measured a panel of inflammatory markers, including C-reactive protein (CRP), interleukin-1beta (IL-1beta), matrix metalloproteinase-1 and -9 (MMP-1 and MMP-9), and white blood cell (WBC) count, before and 4 h after fat challenge (CRP prechallenge only). Heritabilities (h(2) +/- s.d.) of basal inflammatory levels ranged from 16 +/- 8% for MMP-9 (P = 0.02) to 90 +/- 7% for MMP-1 (P < 0.0001). Post-fat load, circulating levels of WBC, MMP-1, and MMP-9 increased by 16, 32, and 43% (all P < 0.0001), with no significant changes in IL-1beta. Postprandial changes over the 4-h period were modestly heritable for WBC (age- and sex-adjusted h(2) = 14 +/- 9%, P = 0.04), but the larger MMP-1 and MMP-9 changes appeared to be independent of additive genetic effects. These results reveal that a high-fat meal induces a considerable inflammatory response. Genetic factors appear to play a significant role influencing basal inflammatory levels but to have minimal influence on post-fat intake inflammatory changes.

SUBMITTER: Cheng YC

PROVIDER: S-EPMC3066005 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Genetic effects on postprandial variations of inflammatory markers in healthy individuals.

Cheng Yu-Ching YC Kao Wen-Hong L WH Mitchell Braxton D BD Sharrett A Richey AR Ryan Kathleen A KA Vogel Robert A RA Shuldiner Alan R AR Pollin Toni I TI

Obesity (Silver Spring, Md.) 20091112 7

Circulating levels of inflammatory markers predict the risk of cardiovascular disease (CVD), mediated perhaps in part by dietary fat intake, through mechanisms only partially understood. To evaluate post-fat load changes in inflammatory markers and genetic influences on these changes, we administered a standardized high-fat meal to 838 related Amish subjects as part of the Heredity and Phenotype Intervention (HAPI) Heart Study and measured a panel of inflammatory markers, including C-reactive pr ...[more]

PMID: 19910936

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Genetic effects on postprandial variations of inflammatory markers in healthy individuals.

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Genetic effects on postprandial variations of inflammatory markers in healthy individuals.

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