Ontology highlight
ABSTRACT:
SUBMITTER: Gregory MS
PROVIDER: S-EPMC3066205 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Gregory Meredith S MS Hackett Caroline G CG Abernathy Emma F EF Lee Karen S KS Saff Rebecca R RR Hohlbaum Andreas M AM Moody Krishna-Sulayman L KS Hobson Maura W MW Jones Alexander A Kolovou Paraskevi P Karray Saoussen S Giani Andrea A John Simon W M SW Chen Dong Feng DF Marshak-Rothstein Ann A Ksander Bruce R BR
PloS one 20110329 3
Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular mechanisms that cause RGC loss remain unclear. The pro-apoptotic molecule, Fas ligand, is a transmembrane protein that can be cleaved from the cell surface by metalloproteinases to release a soluble protein with antagonistic activity. Previous studies documented that constitutive ...[more]