Ontology highlight
ABSTRACT:
SUBMITTER: Chibnik LB
PROVIDER: S-EPMC3066288 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Chibnik Lori B LB Shulman Joshua M JM Leurgans Sue E SE Schneider Julie A JA Wilson Robert S RS Tran Dong D Aubin Cristin C Buchman Aron S AS Heward Christopher B CB Myers Amanda J AJ Hardy John A JA Huentelman Matthew J MJ Corneveaux Jason J JJ Reiman Eric M EM Evans Denis A DA Bennett David A DA De Jager Philip L PL
Annals of neurology 20110309 3
<h4>Objective</h4>Recently, genome-wide association studies have identified 3 new susceptibility loci for Alzheimer's disease (AD), CLU, CR1, and PICALM. We leveraged available neuropsychological and autopsy data from 2 cohort studies to investigate whether these loci are associated with cognitive decline and AD neuropathology.<h4>Methods</h4>The Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP) are longitudinal studies that enroll nondemented subjects and include annual clini ...[more]