Ontology highlight
ABSTRACT:
SUBMITTER: Deshpande DA
PROVIDER: S-EPMC3066567 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Deshpande Deepak A DA Wang Wayne C H WC McIlmoyle Elizabeth L EL Robinett Kathryn S KS Schillinger Rachel M RM An Steven S SS Sham James S K JS Liggett Stephen B SB
Nature medicine 20101024 11
Bitter taste receptors (TAS2Rs) on the tongue probably evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants that, when activated, lead to ASM contraction and bronchospasm. TAS2R agonists such as saccharin, chloroquine and denatonium evoked increased intracellular calcium ([Ca²(+)](i)) in ASM in a Gβγ-, phospholipase Cβ (PLCβ)- and inositol trisphosphate (IP₃) ...[more]