Ontology highlight
ABSTRACT:
SUBMITTER: Jung S
PROVIDER: S-EPMC3067091 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Jung Sascha S Mysliwy Justyna J Spudy Björn B Lorenzen Inken I Reiss Karina K Gelhaus Christoph C Podschun Rainer R Leippe Matthias M Grötzinger Joachim J
Antimicrobial agents and chemotherapy 20101228 3
Despite partial sequence identity and structural similarity, human β-defensin 3 (HBD3) kills Staphylococcus aureus with a 4- to 8-fold higher efficiency than human β-defensin 2 (HBD2), whereas the activities against Escherichia coli are identical. The design and characterization of HBD2/HBD3 chimeric peptides revealed that distinct molecular regions are responsible for their divergent killing properties. Two of the chimeras killed both E. coli and S. aureus with an even higher efficacy than the ...[more]