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Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum ?-lactamase from an Escherichia coli O102-ST405 strain.

ABSTRACT: The sequence of pTN48, a plasmid of the FII-FIB replicon type that encodes a CTX-M-14 enzyme in an Escherichia coli strain of the phylogenetic group D? O102-ST405 clone, was determined. pTN48 is, for the most part, a mosaic of virulence, antibiotic resistance, and addiction system modules found in various other plasmids. The presence of multiple addiction systems indicates that the plasmid should be stably maintained in the E. coli clone, favoring dissemination of the CTX-M-14 enzyme.

SUBMITTER: Billard-Pomares T

PROVIDER: S-EPMC3067099 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum β-lactamase from an Escherichia coli O102-ST405 strain.

Billard-Pomares Typhaine T Tenaillon Olivier O Le Nagard Hervé H Rouy Zoé Z Cruveiller Stéphane S Médigue Claudine C Arlet Guillaume G Denamur Erick E Branger Catherine C

Antimicrobial agents and chemotherapy 20101220 3

The sequence of pTN48, a plasmid of the FII-FIB replicon type that encodes a CTX-M-14 enzyme in an Escherichia coli strain of the phylogenetic group D₂ O102-ST405 clone, was determined. pTN48 is, for the most part, a mosaic of virulence, antibiotic resistance, and addiction system modules found in various other plasmids. The presence of multiple addiction systems indicates that the plasmid should be stably maintained in the E. coli clone, favoring dissemination of the CTX-M-14 enzyme. ...[more]

PMID: 21173179

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