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Integrative expression system for delivery of antibody fragments by lactobacilli.

ABSTRACT: A series of expression cassettes which mediate secretion or surface display of antibody fragments was stably integrated in the chromosome of Lactobacillus paracasei. L. paracasei producing surface-anchored variable domain of llama heavy chain (VHH) (ARP1) directed against rotavirus showed efficient binding to rotavirus and protection in the mouse model of rotavirus infection.

SUBMITTER: Martin MC 

PROVIDER: S-EPMC3067310 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Integrative expression system for delivery of antibody fragments by lactobacilli.

Martín M Cruz MC   Pant Neha N   Ladero Victor V   Günaydin Gökçe G   Andersen Kasper Krogh KK   Alvarez Beatriz B   Martínez Noelia N   Alvarez Miguel A MA   Hammarström Lennart L   Marcotte Harold H  

Applied and environmental microbiology 20110121 6

A series of expression cassettes which mediate secretion or surface display of antibody fragments was stably integrated in the chromosome of Lactobacillus paracasei. L. paracasei producing surface-anchored variable domain of llama heavy chain (VHH) (ARP1) directed against rotavirus showed efficient binding to rotavirus and protection in the mouse model of rotavirus infection. ...[more]

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