Ontology highlight
ABSTRACT:
SUBMITTER: Silmon de Monerri NC
PROVIDER: S-EPMC3067499 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Silmon de Monerri Natalie C NC Flynn Helen R HR Campos Marta G MG Hackett Fiona F Koussis Konstantinos K Withers-Martinez Chrislaine C Skehel J Mark JM Blackman Michael J MJ
Infection and immunity 20110110 3
The protozoan pathogen responsible for the most severe form of human malaria, Plasmodium falciparum, replicates asexually in erythrocytes within a membrane-bound parasitophorous vacuole (PV). Following each round of intracellular growth, the PV membrane (PVM) and host cell membrane rupture to release infectious merozoites in a protease-dependent process called egress. Previous work has shown that, just prior to egress, an essential, subtilisin-like parasite protease called PfSUB1 is discharged i ...[more]