Ontology highlight
ABSTRACT:
SUBMITTER: Smith GA
PROVIDER: S-EPMC30676 | biostudies-literature | 2001 Mar
REPOSITORIES: biostudies-literature
Smith G A GA Gross S P SP Enquist L W LW
Proceedings of the National Academy of Sciences of the United States of America 20010301 6
Alpha herpesviruses infect the vertebrate nervous system resulting in either mild recurrent lesions in mucosal epithelia or fatal encephalitis. Movement of virions within the nervous system is a critical factor in the outcome of infection; however, the dynamics of individual virion transport have never been assessed. Here we visualized and tracked individual viral capsids as they moved in axons away from infected neuronal cell bodies in culture. The observed movement was compatible with fast axo ...[more]