Two DNA translocases synergistically affect chromosome dimer resolution in Bacillus subtilis.
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ABSTRACT:
SUBMITTER: Kaimer C
PROVIDER: S-EPMC3067622 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Two DNA translocases synergistically affect chromosome dimer resolution in Bacillus subtilis.
Kaimer Christine C Schenk Katrin K Graumann Peter L PL
Journal of bacteriology 20110114 6
In Bacillus subtilis, chromosome dimers that block complete segregation of sister chromosomes arise in about 15% of exponentially growing cells. Two dedicated recombinases, RipX and CodV, catalyze the resolution of dimers by site-specific recombination at the dif site, which is located close to the terminus region on the chromosome. We show that the two DNA translocases in B. subtilis, SftA and SpoIIIE, synergistically affect dimer resolution, presumably by positioning the dif sites in close pro ...[more]
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