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Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection.

ABSTRACT: Rv1106c (hsd; 3?-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.

SUBMITTER: Yang X

PROVIDER: S-EPMC3067635 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection.

Yang Xinxin X Gao Jin J Smith Issar I Dubnau Eugenie E Sampson Nicole S NS

Journal of bacteriology 20110121 6

Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection. ...[more]

PMID: 21257778

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