Cerebrovascular risk factors and preclinical memory decline in healthy APOE ε4 homozygotes.

ABSTRACT:

Objective

To characterize the effects of cerebrovascular (CV) risk factors on preclinical memory decline in cognitively normal individuals at 3 levels of genetic risk for Alzheimer disease (AD) based on APOE genotype.

Methods

We performed longitudinal neuropsychological testing on an APOE ε4 enriched cohort, ages 21-97. The long-term memory (LTM) score of the Auditory Verbal Learning Test (AVLT) was the primary outcome measure. Any of 4 CV risk factors (CVany), including hypercholesterolemia (CHOL), prior cigarette use (CIG), diabetes mellitus (DM), and hypertension (HTN), was treated as a dichotomized variable. We estimated the longitudinal effect of age using statistical models that simultaneously modeled the cross-sectional and longitudinal effects of age on AVLT LTM by A

SUBMITTER: Caselli RJ 

PROVIDER: S-EPMC3068011 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature