Ontology highlight
ABSTRACT:
SUBMITTER: Spearman P
PROVIDER: S-EPMC3068023 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Spearman Paul P Lally Michelle A MA Elizaga Marnie M Montefiori David D Tomaras Georgia D GD McElrath M Juliana MJ Hural John J De Rosa Stephen C SC Sato Alicia A Huang Yunda Y Frey Sharon E SE Sato Paul P Donnelly John J Barnett Susan S Corey Lawrence J LJ
The Journal of infectious diseases 20110401 8
<h4>Background</h4>A key missing element in the development of a successful human immunodeficiency virus (HIV) vaccine is an immunogen that can generate broadly cross-neutralizing antibodies against primary isolates of the virus.<h4>Methods</h4>This phase 1 clinical trial employed a DNA prime and subunit envelope protein boost in an attempt to generate cellular and humoral immune responses that might be desirable in a protective HIV vaccine. Priming was performed via intramuscular injection with ...[more]