Ontology highlight
ABSTRACT:
SUBMITTER: Artola-Recolons C
PROVIDER: S-EPMC3068208 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Artola-Recolons Cecilia C Carrasco-López César C Llarrull Leticia I LI Kumarasiri Malika M Lastochkin Elena E Martínez de Ilarduya Iñaki I Meindl Kathrin K Usón Isabel I Mobashery Shahriar S Hermoso Juan A JA
Biochemistry 20110308 13
The crystal structure of the first endolytic peptidoglycan lytic transglycosylase MltE from Escherichia coli is reported here. The degradative activity of this enzyme initiates the process of cell wall recycling, which is an integral event in the existence of bacteria. The structure sheds light on how MltE recognizes its substrate, the cell wall peptidoglycan. It also explains the ability of this endolytic enzyme to cleave in the middle of the peptidoglycan chains. Furthermore, the structure rev ...[more]