Ontology highlight
ABSTRACT:
SUBMITTER: Fukuda D
PROVIDER: S-EPMC3069032 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Fukuda Daisuke D Haines Anthony S AS Song Zhongshu Z Murphy Annabel C AC Hothersall Joanne J Stephens Elton R ER Gurney Rachel R Cox Russell J RJ Crosby John J Willis Christine L CL Simpson Thomas J TJ Thomas Christopher M CM
PloS one 20110331 3
<h4>Background</h4>Understanding how complex antibiotics are synthesised by their producer bacteria is essential for creation of new families of bioactive compounds. Thiomarinols, produced by marine bacteria belonging to the genus Pseudoalteromonas, are hybrids of two independently active species: the pseudomonic acid mixture, mupirocin, which is used clinically against MRSA, and the pyrrothine core of holomycin.<h4>Methodology/principal findings</h4>High throughput DNA sequencing of the complet ...[more]