Dataset Information

Hunter-gatherer genomic diversity suggests a southern African origin for modern humans.

ABSTRACT: Africa is inferred to be the continent of origin for all modern human populations, but the details of human prehistory and evolution in Africa remain largely obscure owing to the complex histories of hundreds of distinct populations. We present data for more than 580,000 SNPs for several hunter-gatherer populations: the Hadza and Sandawe of Tanzania, and the ?Khomani Bushmen of South Africa, including speakers of the nearly extinct N|u language. We find that African hunter-gatherer populations today remain highly differentiated, encompassing major components of variation that are not found in other African populations. Hunter-gatherer populations also tend to have the lowest levels of genome-wide linkage disequilibrium among 27 African populations. We analyzed geographic patterns of linkage disequilibrium and population differentiation, as measured by F(ST), in Africa. The observed patterns are consistent with an origin of modern humans in southern Africa rather than eastern Africa, as is generally assumed. Additionally, genetic variation in African hunter-gatherer populations has been significantly affected by interaction with farmers and herders over the past 5,000 y, through both severe population bottlenecks and sex-biased migration. However, African hunter-gatherer populations continue to maintain the highest levels of genetic diversity in the world.

SUBMITTER: Henn BM

PROVIDER: S-EPMC3069156 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Hunter-gatherer genomic diversity suggests a southern African origin for modern humans.

Henn Brenna M BM Gignoux Christopher R CR Jobin Matthew M Granka Julie M JM Macpherson J M JM Kidd Jeffrey M JM Rodríguez-Botigué Laura L Ramachandran Sohini S Hon Lawrence L Brisbin Abra A Lin Alice A AA Underhill Peter A PA Comas David D Kidd Kenneth K KK Norman Paul J PJ Parham Peter P Bustamante Carlos D CD Mountain Joanna L JL Feldman Marcus W MW

Proceedings of the National Academy of Sciences of the United States of America 20110307 13

Africa is inferred to be the continent of origin for all modern human populations, but the details of human prehistory and evolution in Africa remain largely obscure owing to the complex histories of hundreds of distinct populations. We present data for more than 580,000 SNPs for several hunter-gatherer populations: the Hadza and Sandawe of Tanzania, and the ≠Khomani Bushmen of South Africa, including speakers of the nearly extinct N|u language. We find that African hunter-gatherer populations t ...[more]

PMID: 21383195

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Dataset Information

Hunter-gatherer genomic diversity suggests a southern African origin for modern humans.

Publications

Hunter-gatherer genomic diversity suggests a southern African origin for modern humans.

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