Ontology highlight
ABSTRACT:
SUBMITTER: Baxter EL
PROVIDER: S-EPMC3069162 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Baxter Elizabeth L EL Jennings Patricia A PA Onuchic José N JN
Proceedings of the National Academy of Sciences of the United States of America 20110314 13
MitoNEET is a recently identified drug target for a commonly prescribed diabetes drug, Pioglitazone. It belongs to a previously uncharacterized ancient family of proteins for which the hallmark is the presence of a unique 39 amino acid CDGSH domain. In order to characterize the folding landscape of this novel fold, we performed thermodynamic simulations on MitoNEET using a structure-based model. Additionally, we implement a method of contact map clustering to partition out alternate pathways in ...[more]