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Mechanical regulation of cell function with geometrically modulated elastomeric substrates.


ABSTRACT: We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation. Furthermore, early changes in cytoskeletal contractility predicted later stem cell fate decisions in single cells.

SUBMITTER: Fu J 

PROVIDER: S-EPMC3069358 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Mechanical regulation of cell function with geometrically modulated elastomeric substrates.

Fu Jianping J   Wang Yang-Kao YK   Yang Michael T MT   Desai Ravi A RA   Yu Xiang X   Liu Zhijun Z   Chen Christopher S CS  

Nature methods 20100801 9


We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation. Furthermore, early changes in cytoskeletal contractility predicted later stem cell fate decisions in single cells. ...[more]

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