Ontology highlight
ABSTRACT:
SUBMITTER: Ratti J
PROVIDER: S-EPMC3069465 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Ratti Joyce J Rostkova Elena E Gautel Mathias M Pfuhl Mark M
The Journal of biological chemistry 20110205 14
Myosin-binding protein C (MyBP-C) is a multidomain protein present in the thick filaments of striated muscles and is involved in both sarcomere formation and contraction regulation. The latter function is believed to be located at the N terminus, which is close to the motor domain of myosin. The cardiac isoform of MyBP-C is linked to hypertrophic cardiomyopathy. Here, we use NMR spectroscopy and biophysical and biochemical assays to study the three-dimensional structure and interactions of the c ...[more]