Ontology highlight
ABSTRACT:
SUBMITTER: Calmettes C
PROVIDER: S-EPMC3069468 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Calmettes Charles C Yu Rong-hua RH Silva Leslie P LP Curran Dave D Schriemer David C DC Schryvers Anthony B AB Moraes Trevor F TF
The Journal of biological chemistry 20110205 14
Pathogenic bacteria acquire the essential element iron through specialized uptake pathways that are necessary in the iron-limiting environments of the host. Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B. Because of the critical role they play in the host, these surface-exposed proteins are invariably p ...[more]