Ontology highlight
ABSTRACT:
SUBMITTER: Alter A
PROVIDER: S-EPMC3069725 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Alter Andrea A Huong Nguyen Thu NT Singh Meenakshi M Orlova Marianna M Van Thuc Nguyen N Katoch Kiran K Gao Xiaojiang X Thai Vu Hong VH Ba Nguyen Ngoc NN Carrington Mary M Abel Laurent L Mehra Narinder N Alcaïs Alexandre A Schurr Erwin E
The Journal of infectious diseases 20110501 9
Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy f ...[more]