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Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.


ABSTRACT: Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy families replicated the association of 12 SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 × 10??)-rs2394885 and rs2922997 (marginal multivariate P = 2.1 × 10?? and P = .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the Vietnamese population. The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis.

SUBMITTER: Alter A 

PROVIDER: S-EPMC3069725 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.

Alter Andrea A   Huong Nguyen Thu NT   Singh Meenakshi M   Orlova Marianna M   Van Thuc Nguyen N   Katoch Kiran K   Gao Xiaojiang X   Thai Vu Hong VH   Ba Nguyen Ngoc NN   Carrington Mary M   Abel Laurent L   Mehra Narinder N   Alcaïs Alexandre A   Schurr Erwin E  

The Journal of infectious diseases 20110501 9


Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy f  ...[more]

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