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ABSTRACT:
SUBMITTER: Bunkoczi G
PROVIDER: S-EPMC3069745 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Bunkóczi Gábor G Read Randy J RJ
Acta crystallographica. Section D, Biological crystallography 20110318 Pt 4
In molecular replacement, the quality of models can be improved by transferring information contained in sequence alignment to the template structure. A family of algorithms has been developed that make use of the sequence-similarity score calculated from residue-substitution scores smoothed over nearby residues to delete or downweight parts of the model that are unreliable. These algorithms have been implemented in the program Sculptor, together with well established methods that are in common ...[more]