Ontology highlight
ABSTRACT:
SUBMITTER: Jonsson F
PROVIDER: S-EPMC3069785 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20110323 4
Anaphylaxis is a life-threatening hyperacute immediate hypersensitivity reaction. Classically, it depends on IgE, FcεRI, mast cells, and histamine. However, anaphylaxis can also be induced by IgG antibodies, and an IgG1-induced passive type of systemic anaphylaxis has been reported to depend on basophils. In addition, it was found that neither mast cells nor basophils were required in mouse models of active systemic anaphylaxis. Therefore, we investigated what antibodies, receptors, and cells ar ...[more]