Ontology highlight
ABSTRACT:
SUBMITTER: Kirovski G
PROVIDER: S-EPMC3069916 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Kirovski Georgi G Stevens Axel P AP Czech Barbara B Dettmer Katja K Weiss Thomas S TS Wild Peter P Hartmann Arndt A Bosserhoff Anja K AK Oefner Peter J PJ Hellerbrand Claus C
The American journal of pathology 20110128 3
Recently, we have shown that down-regulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhances the invasive potential and the resistance against cytokines. Here, we aimed at investigating the molecular mechanism underlying this tumor-promoting effect and expanded the analysis to a large series of human HCC tissues. Liquid chromatography tandem mass spectrometry revealed that reduced MTAP expression resulted in higher intra- and extracellular concentrati ...[more]