Ontology highlight
ABSTRACT:
SUBMITTER: Inn KS
PROVIDER: S-EPMC3070481 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Inn Kyung-Soo KS Gack Michaela U MU Tokunaga Fuminori F Shi Mude M Wong Lai-Yee LY Iwai Kazuhiro K Jung Jae U JU
Molecular cell 20110201 3
Upon detection of viral RNA, retinoic acid-inducible gene I (RIG-I) undergoes TRIM25-mediated K63-linked ubiquitination, leading to type I interferon (IFN) production. In this study, we demonstrate that the linear ubiquitin assembly complex (LUBAC), comprised of two RING-IBR-RING (RBR)-containing E3 ligases, HOIL-1L and HOIP, independently targets TRIM25 and RIG-I to effectively suppress virus-induced IFN production. RBR E3 ligase domains of HOIL-1L and HOIP bind and induce proteasomal degradati ...[more]