Ontology highlight
ABSTRACT:
SUBMITTER: Mallevaey T
PROVIDER: S-EPMC3070541 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Mallevaey Thierry T Clarke Andrew J AJ Scott-Browne James P JP Young Mary H MH Roisman Laila C LC Pellicci Daniel G DG Patel Onisha O Vivian Julian P JP Matsuda Jennifer L JL McCluskey James J Godfrey Dale I DI Marrack Philippa P Rossjohn Jamie J Gapin Laurent L
Immunity 20110303 3
The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 Å resolution structure of an autoreactive NKT TCR-phosphatidylinositol-CD1d complex. NKT TCR recognition of self- and foreign antigens was underpinned by a similar mode of germline-encoded recog ...[more]