Ontology highlight
ABSTRACT:
SUBMITTER: Jouhilahti EM
PROVIDER: S-EPMC3070575 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Jouhilahti Eeva-Mari EM Peltonen Sirkku S Callens Tom T Jokinen Elina E Heape Anthony M AM Messiaen Ludwine L Peltonen Juha J
The American journal of pathology 20110201 2
Cutaneous neurofibromas are the hallmarks of neurofibromatosis type 1 (NF1). They are composed of multiple cell types, and traditionally they are believed to arise from small nerve tributaries of the skin. A key finding in the context of this view has been that subpopulations of tumor Schwann cells harbor biallelic inactivation of the NF1 gene (NF1(-/-)). In the present study, our aim was to clarify further the pathogenesis of cutaneous neurofibromas. First, we detected cells expressing multipot ...[more]