Ontology highlight
ABSTRACT:
SUBMITTER: Pickford F
PROVIDER: S-EPMC3070582 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Pickford Fiona F Marcus Jacob J Camargo Luiz Miguel LM Xiao Qiurong Q Graham Danielle D Mo Jan-Rung JR Burkhardt Matthew M Kulkarni Vinayak V Crispino Jamie J Hering Heike H Hutton Michael M
The American journal of pathology 20101223 1
Mutations resulting in progranulin haploinsufficiency cause disease in patients with a subset of frontotemporal lobar degeneration; however, the biological functions of progranulin in the brain remain unknown. To address this subject, the present study initially assessed changes in gene expression and cytokine secretion in rat primary cortical neurons treated with progranulin. Molecular pathways enriched in the progranulin gene set included cell adhesion and cell motility pathways and pathways i ...[more]