Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction.
Ontology highlight
ABSTRACT:
SUBMITTER: Stine MJ
PROVIDER: S-EPMC3070809 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction.
Stine Megan J MJ Wang C Joanne CJ Moriarty Whei F WF Ryu Byungwoo B Cheong Raymond R Westra William H WH Levchenko Andre A Alani Rhoda M RM
Cancer research 20110215 7
Tumor-endothelium interactions are critical for tumor survival and metastasis. Melanomas can rapidly metastasize early in tumor progression, but the dependence of this aggressive behavior on tumor-stromal interaction is poorly understood. To probe the mechanisms involved, we developed a heterotypic coculture methodology, allowing simultaneous tracking of genomic and phenotypic changes in interacting tumor and endothelial cells in vitro. We found a dramatic rearrangement of endothelial cell netwo ...[more]
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