AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.
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ABSTRACT:
SUBMITTER: Gurley SB
PROVIDER: S-EPMC3070917 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.
Gurley Susan B SB Riquier-Brison Anne D M ADM Schnermann Jurgen J Sparks Matthew A MA Allen Andrew M AM Haase Volker H VH Snouwaert John N JN Le Thu H TH McDonough Alicia A AA Koller Beverley H BH Coffman Thomas M TM
Cell metabolism 20110401 4
Hypertension affects more than 1.5 billion people worldwide but the precise cause of elevated blood pressure (BP) cannot be determined in most affected individuals. Nonetheless, blockade of the renin-angiotensin system (RAS) lowers BP in the majority of patients with hypertension. Despite its apparent role in hypertension pathogenesis, the key cellular targets of the RAS that control BP have not been clearly identified. Here we demonstrate that RAS actions in the epithelium of the proximal tubul ...[more]
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