Ontology highlight
ABSTRACT:
SUBMITTER: Hoyle DJ
PROVIDER: S-EPMC3070960 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Hoyle Diego J DJ Rodriguez-Fernandez Imilce A IA Dell'angelica Esteban C EC
Pigment cell & melanoma research 20101217 2
The biogenesis of melanosomes is a multistage process that requires the function of cell-type-specific and ubiquitously expressed proteins. OCA2, the product of the gene defective in oculocutaneous albinism type 2, is a melanosomal membrane protein with restricted expression pattern and a potential role in the trafficking of other proteins to melanosomes. The ubiquitous protein complexes AP-3, BLOC-1, and BLOC-2, which contain as subunits the products of genes defective in various types of Herma ...[more]