Ontology highlight
ABSTRACT:
SUBMITTER: Weimer KE
PROVIDER: S-EPMC3071235 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Weimer Kristin E D KE Juneau Richard A RA Murrah Kyle A KA Pang Bing B Armbruster Chelsie E CE Richardson Stephen H SH Swords W Edward WE
The Journal of infectious diseases 20110110 4
<h4>Background</h4>Otitis media, for which antibiotic treatment failure is increasingly common, is a leading pediatric public health problem.<h4>Methods</h4>In vitro and in vivo studies using the chinchilla model of otitis media were performed using a β-lactamase-producing strain of nontypeable Haemophilus influenzae (NTHi 86-028NP) and an isogenic mutant deficient in β-lactamase production (NTHi 86-028NP bla) to define the roles of biofilm formation and β-lactamase production in antibiotic resi ...[more]