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Safety and immunogenicity of influenza A H5 subunit vaccines: effect of vaccine schedule and antigenic variant.


ABSTRACT: The current US national stockpile of influenza H5 vaccine was produced using the antigen from the strain A/Vietnam/1203/2004 (a clade 1 H5 virus). Recent H5 disease has been caused by antigenically divergent H5 viruses, including A/Indonesia/05/2005 (a clade 2 H5 virus).The influence of schedule on the antibody response to 2 doses of H5 vaccines (one a clade 1 hemagglutinin protein [HA] vaccine and one a clade 2 HA vaccine) containing 90 ?g of antigen was evaluated in healthy adults 18-49 years of age.Two doses of vaccine were required to induce antibody titers ? 1:10 in most subjects. Accelerated schedules were immunogenic, and antibody developed after vaccinations on days 0 and 7, 0 and 14, and 0 and 28, with the day 0 and 7 schedule inducing lower titers than those induced with the other schedules. With mixed vaccine schedules of clade 1 followed by clade 2 vaccine administration, the first vaccination primed for a heterologous boost. The heterologous response was improved when the second vaccination was given 6 months after the first, compared with the response when the second vaccination was given after an interval of 1 month.An accelerated vaccine schedule of injections administered at days 0 and 14 was as immunogenic as a vaccine schedule of injections at days 0 and 28, but both schedules were inferior to a vaccine schedule of injections administered at 0 and 6 months for priming for heterologous vaccine boosting. Clinical Trial Registry Number: NCT00703053.

SUBMITTER: Belshe RB 

PROVIDER: S-EPMC3071280 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Safety and immunogenicity of influenza A H5 subunit vaccines: effect of vaccine schedule and antigenic variant.

Belshe Robert B RB   Frey Sharon E SE   Graham Irene I   Mulligan Mark J MJ   Edupuganti Srilatha S   Jackson Lisa A LA   Wald Anna A   Poland Gregory G   Jacobson Robert R   Keyserling Harry L HL   Spearman Paul P   Hill Heather H   Wolff Mark M  

The Journal of infectious diseases 20110131 5


<h4>Background</h4>The current US national stockpile of influenza H5 vaccine was produced using the antigen from the strain A/Vietnam/1203/2004 (a clade 1 H5 virus). Recent H5 disease has been caused by antigenically divergent H5 viruses, including A/Indonesia/05/2005 (a clade 2 H5 virus).<h4>Methods</h4>The influence of schedule on the antibody response to 2 doses of H5 vaccines (one a clade 1 hemagglutinin protein [HA] vaccine and one a clade 2 HA vaccine) containing 90 μg of antigen was evalu  ...[more]

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