Dataset Information

MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.

ABSTRACT:

Background

Data on the association between the MTHFR 677C>T and ACE D/I polymorphisms and migraine including aura status are conflicting.

Objective

The objective of this study is to perform a systematic review and meta-analysis on this topic.

Methods

We searched for studies published until March 2009 using electronic databases (MEDLINE, EMBASE, Science Citation Index) and reference lists of studies and reviews on the topic. Assessment for eligibility of studies and extraction of data was performed by 2 independent investigators. For each study we calculated the odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.