Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
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ABSTRACT:
SUBMITTER: Cornelis MC
PROVIDER: S-EPMC3071630 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
Cornelis Marilyn C MC Monda Keri L KL Yu Kai K Paynter Nina N Azzato Elizabeth M EM Bennett Siiri N SN Berndt Sonja I SI Boerwinkle Eric E Chanock Stephen S Chatterjee Nilanjan N Couper David D Curhan Gary G Heiss Gerardo G Hu Frank B FB Hunter David J DJ Jacobs Kevin K Jensen Majken K MK Kraft Peter P Landi Maria Teresa MT Nettleton Jennifer A JA Purdue Mark P MP Rajaraman Preetha P Rimm Eric B EB Rose Lynda M LM Rothman Nathaniel N Silverman Debra D Stolzenberg-Solomon Rachael R Subar Amy A Yeager Meredith M Chasman Daniel I DI van Dam Rob M RM Caporaso Neil E NE
PLoS genetics 20110407 4
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP ...[more]
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