Ontology highlight
ABSTRACT:
SUBMITTER: Gregory SM
PROVIDER: S-EPMC3072027 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Gregory Sean M SM Davis Beckley K BK West John A JA Taxman Debra J DJ Matsuzawa Shu-ichi S Reed John C JC Ting Jenny P Y JP Damania Blossom B
Science (New York, N.Y.) 20110101 6015
The NLR (nucleotide binding and oligomerization, leucine-rich repeat) family of proteins senses microbial infections and activates the inflammasome, a multiprotein complex that promotes microbial clearance. Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several human malignancies. We found that KSHV Orf63 is a viral homolog of human NLRP1. Orf63 blocked NLRP1-dependent innate immune responses, including caspase-1 activation and processing of interleukins IL-1β and IL-18. KSHV Orf63 ...[more]