Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC3072069 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Xu Chao C Bian Chuanbing C Lam Robert R Dong Aiping A Min Jinrong J
Nature communications 20110101
CFP1 is a CXXC domain-containing protein and an essential component of the SETD1 histone H3K4 methyltransferase complex. CXXC domain proteins direct different chromatin-modifying activities to various chromatin regions. Here, we report crystal structures of the CFP1 CXXC domain in complex with six different CpG DNA sequences. The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA. ...[more]