Longevity is not influenced by prenatal programming of body size.
Ontology highlight
ABSTRACT:
SUBMITTER: Conover CA
PROVIDER: S-EPMC3072285 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Longevity is not influenced by prenatal programming of body size.
Conover Cheryl A CA Bale Laurie K LK Grell Jacquelyn A JA Mader Jessica R JR Mason Megan A MA
Aging cell 20100609 4
Insulin-like growth factor (IGF) signaling is essential for achieving optimal body size during fetal development, whereas, in the adult, IGFs are associated with aging and age-related diseases. However, it is unclear as to what extent lifespan is influenced by events that occur during development. Here, we provide direct evidence that the exceptional longevity of mice with altered IGF signaling is not linked to prenatal programming of body size. Mice null for pregnancy-associated plasma protein- ...[more]
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