Connectedness of PPI network neighborhoods identifies regulatory hub proteins.
Ontology highlight
ABSTRACT:
SUBMITTER: Fox AD
PROVIDER: S-EPMC3072558 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Connectedness of PPI network neighborhoods identifies regulatory hub proteins.
Fox Andrew D AD Hescott Benjamin J BJ Blumer Anselm C AC Slonim Donna K DK
Bioinformatics (Oxford, England) 20110302 8
<h4>Motivation</h4>With the growing availability of high-throughput protein-protein interaction (PPI) data, it has become possible to consider how a protein's local or global network characteristics predict its function.<h4>Results</h4>We introduce a graph-theoretic approach that identifies key regulatory proteins in an organism by analyzing proteins' local PPI network structure. We apply the method to the yeast genome and describe several properties of the resulting set of regulatory hubs. Fina ...[more]
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