Ontology highlight
ABSTRACT:
SUBMITTER: Grzywacz B
PROVIDER: S-EPMC3072878 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Grzywacz Bartosz B Kataria Nandini N Kataria Niketa N Blazar Bruce R BR Miller Jeffrey S JS Verneris Michael R MR
Blood 20101220 13
Because lymphoid progenitors can give rise to natural killer (NK) cells, NK ontogeny has been considered to be exclusively lymphoid. Here, we show that rare human CD34(+) hematopoietic progenitors develop into NK cells in vitro in the presence of cytokines (interleukin-7, interleukin-15, stem cell factor, and fms-like tyrosine kinase-3 ligand). Adding hydrocortisone and stromal cells greatly increases the frequency of progenitor cells that give rise to NK cells through the recruitment of myeloid ...[more]