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Mechanisms of StpA-mediated RNA remodeling.

ABSTRACT: In bacteria, transcription, translation and gene regulation are highly coupled processes. The achievement of a certain functional structure at a distinct temporal and spatial position is therefore essential for RNA molecules. Proteins that facilitate this proper folding of RNA molecules are called RNA chaperones. Here a prominent example from E. coli is reviewed: the nucleoid associated protein StpA. Based on its various RNA remodeling functions, we propose a mechanistic model that explains how StpA promotes RNA folding. Through transient interactions via the RNA backbone, thereby shielding repelling charges in RNA, it pre-positions the RNA molecules for the successful formation of transition states from encounter complexes.

SUBMITTER: Doetsch M

PROVIDER: S-EPMC3073332 | biostudies-literature | 2010 Nov-Dec

REPOSITORIES: biostudies-literature

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Mechanisms of StpA-mediated RNA remodeling.

Doetsch Martina M Gstrein Thomas T Schroeder Renée R Fürtig Boris B

RNA biology 20101101 6

In bacteria, transcription, translation and gene regulation are highly coupled processes. The achievement of a certain functional structure at a distinct temporal and spatial position is therefore essential for RNA molecules. Proteins that facilitate this proper folding of RNA molecules are called RNA chaperones. Here a prominent example from E. coli is reviewed: the nucleoid associated protein StpA. Based on its various RNA remodeling functions, we propose a mechanistic model that explains how ...[more]

PMID: 21057189

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