Ontology highlight
ABSTRACT:
SUBMITTER: Issigonis M
PROVIDER: S-EPMC3073347 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Issigonis Melanie M Tulina Natalia N de Cuevas Margaret M Brawley Crista C Sandler Laurel L Matunis Erika E
Science (New York, N.Y.) 20091001 5949
Adult stem cells often reside in local microenvironments, or niches. Although niches can contain multiple types of stem cells, the coordinate regulation of stem cell behavior is poorly understood. In the Drosophila testis, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and somatic stem cells. We found that the JAK-STAT signaling target and inhibitor Suppressor of cytokine signaling 36E (SOCS36E) is ...[more]