Ontology highlight
ABSTRACT:
SUBMITTER: Root CM
PROVIDER: S-EPMC3073827 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Root Cory M CM Ko Kang I KI Jafari Amir A Wang Jing W JW
Cell 20110401 1
Internal physiological states influence behavioral decisions. We have investigated the underlying cellular and molecular mechanisms at the first olfactory synapse for starvation modulation of food-search behavior in Drosophila. We found that a local signal by short neuropeptide F (sNPF) and a global metabolic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to modulate olfactory sensitivity. Results from two-photon calcium imaging show that starvation increases presynapt ...[more]