Ontology highlight
ABSTRACT:
SUBMITTER: Spurdle AB
PROVIDER: S-EPMC3074275 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Spurdle Amanda B AB Fahey Paul P Chen Xiaoqing X McGuffog Lesley L Easton Douglas D Peock Susan S Cook Margaret M Simard Jacques J Rebbeck Tim R TR Antoniou Antonis C AC Chenevix-Trench Georgia G
Breast cancer research and treatment 20091118 1
The GSTP1, GSTM1, and GSTT1 detoxification genes all have functional polymorphisms that are common in the general population. A single study of 320 BRCA1/2 carriers previously assessed their effect in BRCA1 or BRCA2 mutation carriers. This study showed no evidence for altered risk of breast cancer for individuals with the GSTT1 and GSTM1 deletion variants, but did report that the GSTP1 Ile105Val (rs1695) variant was associated with increased breast cancer risk in carriers. We investigated the as ...[more]