Ontology highlight
ABSTRACT:
SUBMITTER: Vickers KC
PROVIDER: S-EPMC3074610 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Vickers Kasey C KC Palmisano Brian T BT Shoucri Bassem M BM Shamburek Robert D RD Remaley Alan T AT
Nature cell biology 20110320 4
Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Cellular export of miRNAs to HDL was demonstrated to be regulated by neutral sphingomyelinase. Reconstituted HDL injected into mice retrieved distinct miRNA profiles from normal and atherogenic models. HDL delivery of both exoge ...[more]