Ontology highlight
ABSTRACT:
SUBMITTER: Chuhma N
PROVIDER: S-EPMC3074638 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Chuhma Nao N Tanaka Kenji F KF Hen René R Rayport Stephen S
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110101 4
Dopamine system disorders ranging from movement disorders to addiction and schizophrenia involve striatal medium spiny neurons (MSNs), yet their functional connectivity has been difficult to determine comprehensively. We generated a mouse with conditional channelrhodopsin-2 expression restricted to medium spiny neurons and assessed the specificity and strength of their intrinsic connections in the striatum and their projections to the globus pallidus and the substantia nigra. In the striatum, me ...[more]