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One-pot thioether formation from S-nitrosothiols.


ABSTRACT: Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively convert unstable S-nitrosothiols to stable thioethers in one-pot under very mild conditions is reported. This reaction has the potential to be applied in the detection of protein S-nitrosation.

SUBMITTER: Zhang D 

PROVIDER: S-EPMC3074955 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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One-pot thioether formation from S-nitrosothiols.

Zhang Dehui D   Devarie-Baez Nelmi O NO   Pan Jia J   Wang Hua H   Xian Ming M  

Organic letters 20101116 24


Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively convert unstable S-nitrosothiols to stable thioethers in one-pot under very mild conditions is reported. This reaction has the potential to be applied in the detection of protein S-nitrosation. ...[more]

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